High-Protein Diets Impair Insulin Sensitivity


Dr. Michelle McMacken: This is an incredibly
illustrative and landmark study because it shows that losing weight is not…All plans
for weight loss are not created equal when it comes to metabolic benefit. So you can do all the work of losing weight
on a high protein diet and not eat any of the carbohydrate-rich foods that you love
and still be just as insulin resistant as when you started. That’s what this study shows. Robby: You just heard Dr. Michelle McMacken
right there talk about a very important study. So we’re going to go over that in this video
today. I’ve talked about this many times. It’s our mission here. We’re going to go into individual studies
in detail, explain them, and find the takeaway message. At the end of the day, once we’ve done hundreds
of these we’ll be able to compile a clear view of what the peer-reviewed research says
about what reverses insulin resistance. So, this is an important study. I’ve been emailing Dr. Michelle about this
for a while, and I got Tara involved to really summarize the study, bring it all home so
we can learn from it and see exactly what happened in this study. So, I’m going to turn it over to Tara and
let’s all learn and see what’s going on here. Tara: So this study looked at weight loss
in two different low calorie diets. One was a high protein diet and the other
one was still a calorie-restricted diet but really along the lines of a Standard American
Diet. And this study asked the question, “What happens
to insulin sensitivity when someone loses weight?” Insulin sensitivity is the body’s ability
to utilize insulin. In a healthy body, when insulin is secreted
— it’s a hormone that tells the muscle cells to open up and let glucose into the cell — but
if someone is experiencing insulin resistance, then the cells never get that message. And so the glucose is just left circulating
through the blood, which leaves to high blood glucose or maybe you’ve heard it called high
blood sugars or hyperglycemia. So usually weight loss is associated with
an increase in insulin sensitivity. If someone with prediabetes, let’s say, were
to lose weight, then you would see an improvement in the way that their body utilizes insulin. And in this study that is what you did see
in the Standard American Diet weight loss group. When they lose weight, their insulin sensitivity
increased. But the group that was losing weight on a
high protein diet did not see this effect. In fact, not only did their body not have
an increase in insulin sensitivity, it actually had a decrease and they became more insulin
resistant. Let me just say this again because it’s really
important. The group that ate a high protein diet — even
though it was a calorie restriction diet and they lost 10% of their body weight — they
became more insulin resistant. So this is really important because a low
carbohydrate high protein diet is the standard dietary recommendation given to people who
have some form of diabetes. But this study shows that that way of eating
actually worsens the condition that those people are dealing with. There were another of other ways in which
the high protein diet fell short. The Standard American Diet protein group saw
an increase in glucose metabolism and they also saw a decrease in oxidative stress. Whereas, the high protein group did not see
any increase in glucose metabolism and they actually saw their oxidative stress get worse. And if you don’t know what oxidative stress
is, think cancer and inflammation. So the main take home point that was made
by this study and that we’re trying to emphasize here in this video is that we need to re-think
recommending a high protein diet to people dealing with some form of diabetes. Because even if they lose weight, if they’re
eating a high protein diet they’re going to worsen the disease process within their bodies. Robby: Yes, that is exactly the case, Tara. So there’s a bigger discussion here. And this is just one study. So we’re not trying to draw conclusions from
one study. We’re just going to over time we’re going
to build and show you what is in the peer-reviewed research. This study is very simply, very objectively
showing the objective numbers what happened when a group had a lot of protein and the
other group — the Standard American approach was still too much protein than what we’re
teaching here — but it was less than the higher protein group. So that’s what happened in this particular
study. No study is perfect. The more you look at these studies, the more
you see the flaws. But there are still aspects that we can pull
from. There are still factual information that happened
in these studies and when you look at tens of thousands of them as you’ll see people
like Colin Campbell and the whole the experts that we’re sorta standing on the shoulders
of and Caldwell Esselstein and Dean Ornish and all these people. You’ll see that they have spent their career
looking at hundreds and hundreds and hundreds — thousands of studies — and then they sorta
pull them all together and say “Wait a minute. This is what the research is showing.” So bottom line, this study showed that people
who ate the excess protein — even though they lost weight — they still were experiencing
insulin resistance. And that’s the bottom line. That’s what you need to know. If you want to learn how to reverse insulin
resistance, you’ve got to subscribe to this You Tube channel. We’re going to have a lot more information
on this topic, a lot more science, a lot more peer-reviewed research, testimonials from
our clients, testimonials from other physicians practicing this way. We will show you how to truly reverse insulin
resistance. Tara: And if you guys want to look more into
this study, we’re going to put some notes below and we’re going to put a link to the
actual study so that you can read it and you can take a look for yourself and make your
own conclusions. We’re just giving you guys a spark and a tear
so that you can understand what we’re shown. Robby: Absolutely. Let’s have a discussion about this. We totally geeked out on this. We went deep. I mean I could talk about this study for like
an hour. Tara. Yeah. Robby: We’re just pulling out the important
points and important conclusions. Check it out for yourself. Tara: Please ask some questions below. We’d love to make this a longer discussion. Yeah, please. Robby. Absolutely. We’ll see you in the next video.

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39 thoughts on “High-Protein Diets Impair Insulin Sensitivity

  1. Thanks for that video. As a type 2, I am making the mistake of a protein shake for breakfast. It sounds like I would be better off with a bowl of oatmeal.

  2. well then if I understand this I'm doing a 3 month potatoes challenge might help my weight loss and my diabetes last time I my a1 check was 7

  3. I'm already having sensitivity issues and weight gain, but nothing additional seems wrong with me, and my endo and nutritionist suggested a whole food, lower carb diet which I'm finding means higher protein. Should I be pushing back against this? Because combining their suggestions with the info you showed here, I can only eat lettuce. Lmao

  4. And what about fruit, it's low protein but a lot of simple sugar and a lot of fructose. Should we moderate fruit to a degree in favor of starches?

  5. It makes complete sense from an evolutionary standpoint. When we would be in periods of starvation and had to eat animal products, we weren't getting the glucose for immediate fuel, so the body locks up the cells and prevents hypos. Likely part of the same overall process-gluconeogenesis, that turns protein into glucose for energy.

    If someone is worried about doing low protein/low fat because of muscle loss, there are a few things you can do.
    1: Keep lifting a couple times a week. Your body will try to keep muscle for those activities.
    2: Tomatadine (green tomatoes)and Ursolic acid(apples). were both shown in clinical studies to prevent muscle loss.
    3:Take creatine. Creatine has been used to prevent the muscle wasting effects of MD for years, now.
    4: Amino acids. Not any of them and not BCAA's, but just leucine. Leucine is one of the three BCAAs, but whereas the other two are glucogenic(meaning can be turned into glucose, thus possibly contributing to the insulin resistance), leucine is lipogenic and has also been shown to preserve muscle mass on low calorie diets.

  6. I'll have to read through the study, but the only problem is people ARE improving their insulin resistance with higher protein

  7. Thanks for sharing! I would just add: no one who wants to be healthy shouldn't choose a protein rich diet! So, this message is not just for people with diabetes, but for everyone who wants to be healthy! 😉

  8. I like that you all are talking about this. However, this study has been done on WOMEN only, if I read the title of the study correctly. I think I remember reading that female metabolism reacts differently to any kind of fasting or calorie restriction than men (metabolism and hormonal problems happen in women with certain kinds of intermittent fasting, whereas men do not have problems). It makes me sad that you appear to generalize these results to everyone when this wasn't conducted on both men and women. TLDR: The results of this study may not be true for men.

  9. The body cannot store protein. The body "recycles" through autophagia about 200 grams of protein/day. The body needs about 30-40 gms of exogenous protein via diet…Extra protein is de-aminated and converted to glucose which is why protein is insulinogenic and increases blood sugar. Ergo, extra protein is just a very expensive form of sugar.

  10. And what was considered "High" protein for this study?
    I can eat a 'high' protein vegan diet that maxes out at roughly 90g per day, maybe 130-ish if I had a bean pasta package.
    I don't consider that high. And I'm pretty sure Dr Michael Gregor doesn't either.

  11. Hey Robby. My 15 month old son just got diagnosed type 1 diabetes. I have found Dr. Morse after reading all of Gaps diet and trying to heal him for about 2 weeks on that… It didn't feel right…. He has only been diagnosed for a month so I am trying the best i can to reverse his diagnosis.

  12. what if I m a bodybuilder and cutting for summer.. needs arround 150 grams of protein…. any idea how to do it with ur preachings ? :p

  13. The worsening of the IR in those who lost wt w/high protein diets may explain why the wt is gained back too quickly.

  14. I need your comment on this video please Dr. Ted Naiman – 'Insulin Resistance'

    https://www.youtube.com/watch?v=Jd8QFD5Ht18
    Thank you in advance

  15. I don't like this study. Its basically a stawman study. Its not a low-carb high-protein diet it is a high-carb high-protein diet that they test. They barely decreased the carb intake on the higher protein diet (48% to 43%). Most people that talk about high protein diet expect low carb intake. I'm not saying you would have different results I just think this study was totally worthless and should not be reported on.

  16. What about large guys like myself 6 ft 3 and 285 pounds. How much grams of protein would I need daily? My adrenals get taxed easily on high carb diets.

  17. You should run this regularly to inform and/or remind others about insulin resistance, oxidation, and high protein diets. Thanks so much!!!!

  18. This is huge!! I've been asking this question for a long time. Thanks! WFPB is best. In reversing the 2 this is paramount.

  19. This extremely flawed study was performed on "postmenopausal women with obesity" So EVERYONE take it with a grain of salt. Also as others have pointed out the High Protein Group still consumed high levels of carbohydrates, whereas most high protein diets do not. There are more studies that show more lean mass means higher insulin sensitivity/lower resistance.

  20. What about keto diet? Keto diet is low protein (up to 15%), very low carb (up to 10%), high fat(min 75%) diet… Keto Diet Producers, present studies showing that low-sugar diets, low protein and a lot of fat, improve both, insulin sensitivity and total health … They have a lot of studies …

  21. I know one thing for sure. When I was on a high fat low carb diet I felt crappy and I needed insulin even though I was exercising. Since I started a high carb low fat low protein diet I have been able to stop using insulin even though I have been exercising less. I feel much better and I am happier. My A1C is lower, my fasting blood sugar is lower, my cholesterol numbers are way better than before. I am never going back. I thank God that I have discovered these things. Thank you so much Robbie & Cyrus.

  22. I love the comments. All the same old arguments by people who think they are experts because they have read a fad diet book or two. Thank you Mastering Diabetes Team. You guys rock! You have helped so many people improve their insulin sensitivity, and in many cases get off all their diabetic medications. And you've shown all of us who are members of your wonderful program how to follow the science.

  23. What about intermittent fasting? Is it effective with either diet? Buddy of mine has been doing it for about 3yrs, and he lost 120lbs, and lab results are awesome. He was diabetic, had high blood pressure, and suffered from severe migraines. Ever since fasting, he says that he is a new man. I'll try anything. I'm tired of being sick.

  24. I am T2D, been seeing/reading all the good stories regarding ‘carnivore’ diet; done it for 1 month & got elevated blood-sugars & a diabetic-toe-blister developed too! (Not good) ☹️Now going back to a ‘Keto’ diet, i was tired of tracking macros but such is life! Your video has confirmed my suspicions with the ‘carnivorous’ (high protein) approach. Thank you 👍

  25. type 2 diabetes is insulin resistance in the liver not muscle…. insulin resistance in muscle means increased fatty acid oxidation, the muscle just prefers using fat as a fuel not glucose. Stop confusing ppl, type 2 diabetes is a hepatic problem not muscle problem. this study also makes no sense as it completely ignores the two macronutrients that are most important for metabolism(FAT and GLUCOSE). Protein is not a fuel it is only used as a fuel when converted to glucose through gluconeogenesis. Why study a macronutrient that has no relevance in mitochondrial physiology. If we are talking about metabolism protein is neutral…… the argument is between fat and glucose. Complete waste of time study in my opinion the only thing that can be garnered from this is the thermic benefits of protein as its takes so much energy to turn it into glucose before it can even smell a mitochondria.

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